Matches in DBpedia 2016-04 for { <http://wikidata.dbpedia.org/resource/Q18033837> ?p ?o }
Showing triples 1 to 17 of
17
with 100 triples per page.
- Q18033837 subject Q7424714.
- Q18033837 abstract "Serine/threonine-protein kinase LATS1 is an enzyme that in humans is encoded by the LATS1 gene.It has been associated with the Hippo signaling pathway.The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.".
- Q18033837 entrezgene "9113".
- Q18033837 wikiPageWikiLink Q15325366.
- Q18033837 wikiPageWikiLink Q18032606.
- Q18033837 wikiPageWikiLink Q5768379.
- Q18033837 wikiPageWikiLink Q7187.
- Q18033837 wikiPageWikiLink Q7424714.
- Q18033837 wikiPageWikiLink Q8047.
- Q18033837 wikiPageWikiLink Q896177.
- Q18033837 type Biomolecule.
- Q18033837 type Protein.
- Q18033837 type Thing.
- Q18033837 type Q206229.
- Q18033837 type Q8054.
- Q18033837 comment "Serine/threonine-protein kinase LATS1 is an enzyme that in humans is encoded by the LATS1 gene.It has been associated with the Hippo signaling pathway.The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase.".
- Q18033837 label "LATS1".