Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/WNT6> ?p ?o }
Showing triples 1 to 55 of
55
with 100 triples per page.
- WNT6 abstract "Wingless-type MMTV integration site family, member 6, also known as WNT6, is a human gene.The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family, which are involved in the Wnt signaling pathway. It is overexpressed in cervical cancer cell line and strongly coexpressed with another family member, WNT10A, in colorectal cancer cell line. The gene overexpression may play key roles in carcinogenesis. This gene and the WNT10A gene are clustered in the chromosome 2q35 region. The protein encoded by this gene is 97% identical to the mouse Wnt6 protein at the amino acid level.Role in DevelopmentWnt6 plays a role in the formation and maturation of different embryonic structures, namely the fetal heart, ventral body wall, and somite derived structures. Wnt6, through the canonical Wnt signaling pathway, inhibits the induction of cardiogenic mesoderm. For this reason, Wnt6 inhibitors like Cerberus must be present to allow the cells to be induced. Knockout models show that without Wnt6 the fetus develops an enlarged heart, while upregulating Wnt6 results in the heart being underdeveloped. Several Wnts, including Wnt6, have shown to be involved in the formation of the ventral body wall and when inhibited result in birth defects such as failure of the wall to close, hypoplasia of the musculature, and other defects. Following the formation of the somites from the Paraxial Mesoderm, the outermost cells of the somites undergo a mesenchymal to epithelial transition. Wnt6 is expressed by the overlying ectoderm and promotes the production of Paraxis, which facilitates the transition. While many structures will still form if Wnt6 is knocked out, the structures (ribs, vertebra, and muscles) are fused and not organized properly. On the other hand, if Wnt6 is upregulated, muscle in the limbs and surrounding areas are decreased as the mesenchymal progenitor cells that migrate and become the muscle are locked in the somite as epithelial cells.".
- WNT6 arm "q".
- WNT6 band "35".
- WNT6 chromosome "2".
- WNT6 entrezgene "7475".
- WNT6 hgncid "12785".
- WNT6 omim "604663".
- WNT6 refseq "NM_006522".
- WNT6 symbol "WNT6".
- WNT6 uniprot "Q9Y6F9".
- WNT6 wikiPageID "19200931".
- WNT6 wikiPageLength "5171".
- WNT6 wikiPageOutDegree "9".
- WNT6 wikiPageRevisionID "687945748".
- WNT6 wikiPageWikiLink Carcinogenesis.
- WNT6 wikiPageWikiLink Cervical_cancer.
- WNT6 wikiPageWikiLink Colorectal_cancer.
- WNT6 wikiPageWikiLink Gene.
- WNT6 wikiPageWikiLink Human_embryogenesis.
- WNT6 wikiPageWikiLink Immortalised_cell_line.
- WNT6 wikiPageWikiLink WNT10A.
- WNT6 wikiPageWikiLink Wnt_signaling_pathway.
- WNT6 wikiPageWikiLinkText "WNT6".
- WNT6 wikiPageWikiLinkText "Wnt6".
- WNT6 arm "q".
- WNT6 band "35".
- WNT6 chromosome "2".
- WNT6 entrezgene "7475".
- WNT6 hgncid "12785".
- WNT6 name "wingless-type MMTV integration site family, member 6".
- WNT6 omim "604663".
- WNT6 refseq "NM_006522".
- WNT6 symbol "WNT6".
- WNT6 uniprot "Q9Y6F9".
- WNT6 wikiPageUsesTemplate Template:Gene-2-stub.
- WNT6 wikiPageUsesTemplate Template:Infobox_protein.
- WNT6 wikiPageUsesTemplate Template:NLM_content.
- WNT6 wikiPageUsesTemplate Template:Reflist.
- WNT6 wikiPageUsesTemplate Template:Wnt_signaling_pathway.
- WNT6 hypernym Gene.
- WNT6 type Biomolecule.
- WNT6 type Protein.
- WNT6 type Institute.
- WNT6 type Source.
- WNT6 type Thing.
- WNT6 type Q206229.
- WNT6 type Q8054.
- WNT6 comment "Wingless-type MMTV integration site family, member 6, also known as WNT6, is a human gene.The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family, which are involved in the Wnt signaling pathway.".
- WNT6 label "WNT6".
- WNT6 sameAs Q7953613.
- WNT6 sameAs m.04ld3sr.
- WNT6 sameAs Q7953613.
- WNT6 wasDerivedFrom WNT6?oldid=687945748.
- WNT6 isPrimaryTopicOf WNT6.
- WNT6 name "wingless-type MMTV integration site family, member 6".