Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/Ku_(protein)> ?p ?o }
- Ku_(protein) abstract "Ku is a protein that binds to DNA double-strand break ends and is required for the non-homologous end joining (NHEJ) pathway of DNA repair. Ku is evolutionarily conserved from bacteria to humans. The ancestral bacterial Ku is a homodimer (two copies of the same protein bound to each other). Eukaryotic Ku is a heterodimer of two polypeptides, Ku70 (XRCC6) and Ku80 (XRCC5), so named because the molecular weight of the human Ku proteins is around 70 kDa and 80 kDa. The two Ku subunits form a basket-shaped structure that threads onto the DNA end. Once bound, Ku can slide down the DNA strand, allowing more Ku molecules to thread onto the end. In higher eukaryotes, Ku forms a complex with the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) to form the full DNA-dependent protein kinase, DNA-PK. Ku is thought to function as a molecular scaffold to which other proteins involved in NHEJ can bind, orienting the double-strand break for ligation.The Ku70 and Ku80 proteins consist of three structural domains. The N-terminal domain is an alpha/beta domain. This domain only makes a small contribution to the dimer interface. The domain comprises a six stranded beta sheet of the Rossman fold. The central domain of Ku70 and Ku80 is a DNA-binding beta-barrel domain. Ku makes only a few contacts with the sugar-phosphate backbone, and none with the DNA bases, but it fits sterically to major and minor groove contours forming a ring that encircles duplex DNA, cradling two full turns of the DNA molecule. By forming a bridge between the broken DNA ends, Ku acts to structurally support and align the DNA ends, to protect them from degradation, and to prevent promiscuous binding to unbroken DNA. Ku effectively aligns the DNA, while still allowing access of polymerases, nucleases and ligases to the broken DNA ends to promote end joining. The C-terminal arm is an alpha helical region which embraces the central beta-barrel domain of the opposite subunit. In some cases a fourth domain is present at the C-terminus, which binds to DNA-dependent protein kinase catalytic subunit.Both subunits of Ku have been experimentally knocked out in mice. These mice exhibit chromosomal instability, indicating that NHEJ is important for genome maintenance.In many organisms, Ku has additional functions at telomeres in addition to its role in DNA repair.Abundance of Ku80 seems to be related to species longevity.".
- Ku_(protein) arm "q".
- Ku_(protein) band "11".
- Ku_(protein) band "35".
- Ku_(protein) chromosome "2".
- Ku_(protein) chromosome "22".
- Ku_(protein) entrezgene "2547".
- Ku_(protein) entrezgene "7520".
- Ku_(protein) hgncid "12833".
- Ku_(protein) hgncid "4055".
- Ku_(protein) locusSupplementaryData "-q13".
- Ku_(protein) omim "152690".
- Ku_(protein) omim "194364".
- Ku_(protein) pdb "1JEY".
- Ku_(protein) refseq "NM_001469".
- Ku_(protein) refseq "NM_021141".
- Ku_(protein) symbol "Ku".
- Ku_(protein) symbol "Ku70, G22P1".
- Ku_(protein) symbol "Ku80".
- Ku_(protein) symbol "Ku_C".
- Ku_(protein) symbol "Ku_N".
- Ku_(protein) symbol "Ku_PK_bind".
- Ku_(protein) symbol "XRCC5".
- Ku_(protein) symbol "XRCC6".
- Ku_(protein) thumbnail Ku_bound_to_DNA.png?width=300.
- Ku_(protein) uniprot "P12956".
- Ku_(protein) uniprot "P13010".
- Ku_(protein) wikiPageID "5058843".
- Ku_(protein) wikiPageLength "11094".
- Ku_(protein) wikiPageOutDegree "43".
- Ku_(protein) wikiPageRevisionID "687977395".
- Ku_(protein) wikiPageWikiLink Alpha_helix.
- Ku_(protein) wikiPageWikiLink Beta_barrel.
- Ku_(protein) wikiPageWikiLink Beta_sheet.
- Ku_(protein) wikiPageWikiLink C-terminus.
- Ku_(protein) wikiPageWikiLink Category:DNA_repair.
- Ku_(protein) wikiPageWikiLink Category:Protein_domains.
- Ku_(protein) wikiPageWikiLink Category:Protein_families.
- Ku_(protein) wikiPageWikiLink Category:Proteins.
- Ku_(protein) wikiPageWikiLink Chromosome_abnormality.
- Ku_(protein) wikiPageWikiLink DNA.
- Ku_(protein) wikiPageWikiLink DNA-PKcs.
- Ku_(protein) wikiPageWikiLink DNA_damage_theory_of_aging.
- Ku_(protein) wikiPageWikiLink DNA_repair.
- Ku_(protein) wikiPageWikiLink Knockout_mouse.
- Ku_(protein) wikiPageWikiLink Ku70.
- Ku_(protein) wikiPageWikiLink Ku80.
- Ku_(protein) wikiPageWikiLink Ligase.
- Ku_(protein) wikiPageWikiLink Molecular_mass.
- Ku_(protein) wikiPageWikiLink N-terminus.
- Ku_(protein) wikiPageWikiLink Non-homologous_end_joining.
- Ku_(protein) wikiPageWikiLink Nuclease.
- Ku_(protein) wikiPageWikiLink Nucleic_acid_double_helix.
- Ku_(protein) wikiPageWikiLink Nucleobase.
- Ku_(protein) wikiPageWikiLink Peptide.
- Ku_(protein) wikiPageWikiLink Polymerase.
- Ku_(protein) wikiPageWikiLink Protein_dimer.
- Ku_(protein) wikiPageWikiLink Protein_domain.
- Ku_(protein) wikiPageWikiLink Protein_kinase.
- Ku_(protein) wikiPageWikiLink Protein_subunit.
- Ku_(protein) wikiPageWikiLink Rossmann_fold.
- Ku_(protein) wikiPageWikiLink Steric_effects.
- Ku_(protein) wikiPageWikiLink Sticky_and_blunt_ends.
- Ku_(protein) wikiPageWikiLink Structure.
- Ku_(protein) wikiPageWikiLinkText "KU protein".
- Ku_(protein) wikiPageWikiLinkText "Ku (protein)".
- Ku_(protein) wikiPageWikiLinkText "Ku heterodimer".
- Ku_(protein) wikiPageWikiLinkText "Ku protein".
- Ku_(protein) wikiPageWikiLinkText "Ku".
- Ku_(protein) wikiPageWikiLinkText "Ku-70".
- Ku_(protein) wikiPageWikiLinkText "Ku70/80".
- Ku_(protein) altsymbols "Ku70, G22P1".
- Ku_(protein) altsymbols "Ku80".
- Ku_(protein) arm "q".
- Ku_(protein) band "11".
- Ku_(protein) band "35".
- Ku_(protein) caption "259200.0".
- Ku_(protein) caption "Crystal structure of human Ku bound to DNA. Ku70 is shown in purple, Ku80 in blue, and the DNA strand in green.".
- Ku_(protein) caption "crystal structure of the ku heterodimer bound to dna".
- Ku_(protein) caption "crystal structure of the ku heterodimer".
- Ku_(protein) chromosome "2".
- Ku_(protein) chromosome "22".
- Ku_(protein) entrezgene "2547".
- Ku_(protein) entrezgene "7520".
- Ku_(protein) hgncid "12833".
- Ku_(protein) hgncid "4055".
- Ku_(protein) interpro "IPR005160".
- Ku_(protein) interpro "IPR005161".
- Ku_(protein) interpro "IPR006164".
- Ku_(protein) interpro "IPR014893".
- Ku_(protein) locussupplementarydata "-q13".
- Ku_(protein) name "Ku C terminal domain like".
- Ku_(protein) name "Ku70/Ku80 C-terminal arm".
- Ku_(protein) name "Ku70/Ku80 N-terminal alpha/beta domain".
- Ku_(protein) name "Ku70/Ku80 beta-barrel domain".
- Ku_(protein) name "X-ray repair".
- Ku_(protein) name "cross-complementing 5".
- Ku_(protein) name "cross-complementing 6".
- Ku_(protein) omim "152690".
- Ku_(protein) omim "194364".