Matches in DBpedia 2016-04 for { ?s ?p "K-Ras(G12C) inhibitor 6 is an irreversible inhibitor of oncogenic K-Ras(G12C), subverting the native nucleotide preference to favour GDP over GTP. Its family of inhibitors allosterically control GTP affinity and effector interactions by fitting inside a \"pocket\", or binding site, of mutant K-Ras.Investigators and pathologists previously thought that K-Ras is undruggable. However, Dr. Kevan M."@en }
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- K-Ras(G12C)_inhibitor_6 comment "K-Ras(G12C) inhibitor 6 is an irreversible inhibitor of oncogenic K-Ras(G12C), subverting the native nucleotide preference to favour GDP over GTP. Its family of inhibitors allosterically control GTP affinity and effector interactions by fitting inside a \"pocket\", or binding site, of mutant K-Ras.Investigators and pathologists previously thought that K-Ras is undruggable. However, Dr. Kevan M.".