Matches in DBpedia 2016-04 for { ?s ?p "Fbx15, otherwise known as Fbxo15, is a protein expressed in undifferentiated embryonic stem cells.It is expressed during coexpression of Oct3/4, c-Myc, Klf4, and SOX2, four genes identified to be important in embryonic stem cell self-renewal and differentiation repression.In mice having a beta-galactosidase gene knocked into the Fbx15 locus, stain was detected in ES cells, early embryos (from two-cell to blastocyst stages), and testis tissue.There is an enhancer site upstream of the Fbx15-encoding transcription gene that contains an octamer-like binding motif and a Sox-like binding motif.Reporter gene analyses demonstrated that the ES cell-specific expression required this 18-bp enhancer element located approximately 500 nucleotides upstream from the transcription initiation site. "@en }
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- Fbx15 comment "Fbx15, otherwise known as Fbxo15, is a protein expressed in undifferentiated embryonic stem cells.It is expressed during coexpression of Oct3/4, c-Myc, Klf4, and SOX2, four genes identified to be important in embryonic stem cell self-renewal and differentiation repression.In mice having a beta-galactosidase gene knocked into the Fbx15 locus, stain was detected in ES cells, early embryos (from two-cell to blastocyst stages), and testis tissue.There is an enhancer site upstream of the Fbx15-encoding transcription gene that contains an octamer-like binding motif and a Sox-like binding motif.Reporter gene analyses demonstrated that the ES cell-specific expression required this 18-bp enhancer element located approximately 500 nucleotides upstream from the transcription initiation site. ".
- Q5439264 comment "Fbx15, otherwise known as Fbxo15, is a protein expressed in undifferentiated embryonic stem cells.It is expressed during coexpression of Oct3/4, c-Myc, Klf4, and SOX2, four genes identified to be important in embryonic stem cell self-renewal and differentiation repression.In mice having a beta-galactosidase gene knocked into the Fbx15 locus, stain was detected in ES cells, early embryos (from two-cell to blastocyst stages), and testis tissue.There is an enhancer site upstream of the Fbx15-encoding transcription gene that contains an octamer-like binding motif and a Sox-like binding motif.Reporter gene analyses demonstrated that the ES cell-specific expression required this 18-bp enhancer element located approximately 500 nucleotides upstream from the transcription initiation site. ".