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- Afamelanotide abstract "Note: this article describes afamelanotide which is also known by the name melanotan-1. afamelanotide should not be confused with melanotan II.Afamelanotide /ˌæfəmɛˈlænɵtaɪd/, originally developed at the University of Arizona, is a synthetic analog of the naturally occurring melanocortin peptide hormone alpha-melanocyte stimulating hormone (α-MSH) that has been shown to induce skin pigmentation through melanogenesis and thereby subsequently reduce sun (UV) damage to UV exposed skin in preliminary studies and clinical trials. Its amino acid sequence is Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2 or [Nle4, D-Phe7]-α-MSH.Afamelanotide is the International Nonproprietary Name for the molecule [Nle4, D-Phe7]α-MSH initially researched and developed as melanotan-1 /mɛˈlænɵtæn/ and later, CUV1647 [by Clinuvel]. A marketing trade name for one brand of afamelanotide was approved in 2010 by the European Medicines Agency (EMA) Name Review Group (NRG) and the Agency's Committee for Human Medicinal Products (CHMP) as Scenesse (pronounced "sen-esse"). On May 5, 2010 the Italian Medicines Agency (AIFA - Agenzia Italiana del Farmaco) became the first governmental health organization ever (even before the drug received approval in Europe) to authorize afamelanotide as a medicine for therapeutic treatment of Italian citizens to reduce painful photosensitivity stemming from the orphan disease erythropoietic protoporphyria (EPP). This approval allowed the drug to be immediately available for prescription in Italy and reimbursable under the country's national health system. Authorities in Switzerland have also allowed prescription of the drug for EPP with reimbursement approved by two unnamed insurers Afamelanotide is currently being clinically trialled in the form of a "grain of rice" sized bioabsorbable subcutaneous implant as a potential therapeutic photoprotection inducing agent for a series of light related skin indications as well as a potential dermal repigmentation agent for vitiligo. The drug molecule [Nle4, D-Phe7]α-MSH has recently Oct 24 2014 been approved in Europe for the treatment of EPP. Unlicensed and untested powders sold as "melanotan" are found on the Internet and are reported to be used by tens of thousands of members of the general public.Multiple regulatory bodies have warned consumers the peptides may be unsafe and ineffective in usage, with one regulatory agency warning that consumers who purchase any product labeled "melanotan" risk buying a counterfeit drug. Clinuvel Pharmaceuticals, the company developing afamelanotide, and medical researchers have warned consumers that counterfeit products sold using the names "melanotan I and II", could "pose a hazard to public health". Clinuvel has stated publicly that products sold online as "melanotan" are not afamelanotide.".
- Afamelanotide atcPrefix "D02".
- Afamelanotide atcSuffix "BB02".
- Afamelanotide casNumber "75921-69-6".
- Afamelanotide fdaUniiCode "QW68W3J66U".
- Afamelanotide iupacName "N-acetyl-(L)-seryl-(L)-tyrosyl-(L)-seryl-(L)-norleucyl-(L)-α-glutamyl-(L)-histidyl-(D)-phenylalanyl-(L)-arginyl-(L)-tryptophylglycyl-(L)-lysyl-(L)-prolyl-(L)-valinamide".
- Afamelanotide pubchem "16154396".
- Afamelanotide thumbnail Melanotan.png?width=300.
- Afamelanotide wikiPageExternalLink summary.cgi?sid=734258.
- Afamelanotide wikiPageExternalLink www.clinuvel.com.
- Afamelanotide wikiPageID "17981721".
- Afamelanotide wikiPageRevisionID "633382726".
- Afamelanotide atcPrefix "D02".
- Afamelanotide atcSuffix "BB02".
- Afamelanotide c "78".
- Afamelanotide casNumber "75921".
- Afamelanotide chembl "441738".
- Afamelanotide chemspiderid "17310725".
- Afamelanotide eliminationHalfLife "-6120.0".
- Afamelanotide h "111".
- Afamelanotide hasPhotoCollection Afamelanotide.
- Afamelanotide inchi "1".
- Afamelanotide inchikey "UAHFGYDRQSXQEB-LEBBXHLNBN".
- Afamelanotide iupacName "N-acetyl-(L)-seryl-(L)-tyrosyl-(L)-seryl-(L)-norleucyl-(L)-α-glutamyl-(L)-histidyl-(D)-phenylalanyl-(L)-arginyl-(L)-tryptophylglycyl-(L)-lysyl-(L)-prolyl-(L)-valinamide".
- Afamelanotide legalStatus "Non-regulated".
- Afamelanotide molecularWeight "1646.845".
- Afamelanotide n "21".
- Afamelanotide o "19".
- Afamelanotide pubchem "16154396".
- Afamelanotide routesOfAdministration Insufflation_(medicine).
- Afamelanotide routesOfAdministration Intramuscular_injection.
- Afamelanotide routesOfAdministration Intravenous_therapy.
- Afamelanotide routesOfAdministration Subcutaneous_injection.
- Afamelanotide routesOfAdministration Transdermal_implant.
- Afamelanotide smiles "O=C".
- Afamelanotide stdinchi "1".
- Afamelanotide stdinchikey "UAHFGYDRQSXQEB-LEBBXHLNSA-N".
- Afamelanotide synonyms "Melanotan; Melanotan-1; Melanotan I; CUV1647; EPT1647; NDP-MSH; [Nle4, (D)-Phe7]α-MSH".
- Afamelanotide unii "QW68W3J66U".
- Afamelanotide verifiedfields "changed".
- Afamelanotide verifiedrevid "477364562".
- Afamelanotide watchedfields "changed".
- Afamelanotide subject Category:Melanocortin_receptor_agonists.
- Afamelanotide subject Category:Peptide_hormones.
- Afamelanotide type Abstraction100002137.
- Afamelanotide type BodySubstance105263850.
- Afamelanotide type Hormone105407119.
- Afamelanotide type LiquidBodySubstance105397468.
- Afamelanotide type Matter100020827.
- Afamelanotide type Part113809207.
- Afamelanotide type PeptideHormones.
- Afamelanotide type PhysicalEntity100001930.
- Afamelanotide type Relation100031921.
- Afamelanotide type Secretion105404728.
- Afamelanotide type Substance100019613.
- Afamelanotide type Drug.
- Afamelanotide type ChemicalSubstanceType.
- Afamelanotide type Thing.
- Afamelanotide type Q8386.
- Afamelanotide comment "Note: this article describes afamelanotide which is also known by the name melanotan-1.".
- Afamelanotide label "Afamelanotide".
- Afamelanotide label "Afamelanotide".
- Afamelanotide label "Afamelanotide".
- Afamelanotide label "Melanotan I".
- Afamelanotide sameAs Melanotan_I.
- Afamelanotide sameAs Afamelanotide.
- Afamelanotide sameAs Afamelanotide.
- Afamelanotide sameAs m.05h5nc0.
- Afamelanotide sameAs Q410794.
- Afamelanotide sameAs Q410794.
- Afamelanotide sameAs Afamelanotide.
- Afamelanotide wasDerivedFrom Afamelanotide?oldid=633382726.
- Afamelanotide depiction Melanotan.png.
- Afamelanotide isPrimaryTopicOf Afamelanotide.