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- Sialoadhesin abstract "Sialoadhesin is a cell adhesion molecule found on the surface of certain cells of the immune system called macrophages. It is found in especially high amounts on macrophages of the spleen, liver, lymph node, bone marrow, colon, and lungs. Also, in patients suffering from rheumatoid arthritis, the protein has been found in great amounts on macrophages of the affected tissues. It is defined as an I-type lectin, since it contains 17 immunoglobulin (Ig) domains (one variable domain and 16 constant domains), and thus also belongs to the immunoglobulin superfamily (IgSF). Sialoadhesin binds to certain molecules called sialic acids. During this binding process a salt bridge (protein) is formed between a highly conserved arginine residue (from the v-set domain to the 3'-sialyllactose) and the carboxylate group of the sialic acid. Since sialoadhesin binds sialic acids with its N-terminal IgV-domain, it is also a member of the SIGLEC family. Alternate names for sialoadhesin include siglec-1 and CD169 (cluster of differentiation 169).Sialoadhesin predominantly binds neutrophils, but can also bind monocytes, natural killer cells, B cells and a subset of cytotoxic T cells by interacting with sialic acid molecules in the ligands on their surfaces.Sialaodhesin (CD169) positive macrophages, along with mesenchymal stem cells and beta-adrenergic neurons, form the hematopoietic stem cell niche in the bone marrow. CD169+ macrophages mediate signaling between the various cells and seem to promote hematopoietic stem cell retention to the niche.".
- Sialoadhesin arm "p".
- Sialoadhesin band "13".
- Sialoadhesin chromosome "20".
- Sialoadhesin entrezgene "6614".
- Sialoadhesin hgncid "11127".
- Sialoadhesin omim "600751".
- Sialoadhesin pdb "2BVE".
- Sialoadhesin refseq "NM_023068".
- Sialoadhesin symbol "SIGLEC1".
- Sialoadhesin symbol "SN, CD169".
- Sialoadhesin thumbnail 2BVE.pdb.jpg?width=300.
- Sialoadhesin uniprot "Q9BZZ2".
- Sialoadhesin wikiPageID "9718203".
- Sialoadhesin wikiPageLength "3947".
- Sialoadhesin wikiPageOutDegree "20".
- Sialoadhesin wikiPageRevisionID "641601015".
- Sialoadhesin wikiPageWikiLink Arginine.
- Sialoadhesin wikiPageWikiLink B_cell.
- Sialoadhesin wikiPageWikiLink Category:Clusters_of_differentiation.
- Sialoadhesin wikiPageWikiLink Category:SIGLEC.
- Sialoadhesin wikiPageWikiLink Cell_adhesion_molecule.
- Sialoadhesin wikiPageWikiLink Cluster_of_differentiation.
- Sialoadhesin wikiPageWikiLink Cytotoxic_T_cell.
- Sialoadhesin wikiPageWikiLink Immune_system.
- Sialoadhesin wikiPageWikiLink Immunoglobulin_domain.
- Sialoadhesin wikiPageWikiLink Immunoglobulin_superfamily.
- Sialoadhesin wikiPageWikiLink Lectin.
- Sialoadhesin wikiPageWikiLink Ligand.
- Sialoadhesin wikiPageWikiLink Macrophage.
- Sialoadhesin wikiPageWikiLink Monocyte.
- Sialoadhesin wikiPageWikiLink N-terminal.
- Sialoadhesin wikiPageWikiLink N-terminus.
- Sialoadhesin wikiPageWikiLink Natural_killer_cell.
- Sialoadhesin wikiPageWikiLink Neutrophil.
- Sialoadhesin wikiPageWikiLink Neutrophil_granulocyte.
- Sialoadhesin wikiPageWikiLink SIGLEC.
- Sialoadhesin wikiPageWikiLink Salt_bridge_(protein).
- Sialoadhesin wikiPageWikiLink Salt_bridge_(protein_and_supramolecular).
- Sialoadhesin wikiPageWikiLink Sialic_acid.
- Sialoadhesin wikiPageWikiLinkText "Sialoadhesin".
- Sialoadhesin wikiPageWikiLinkText "sialoadhesin".
- Sialoadhesin altsymbols "SN, CD169".
- Sialoadhesin arm "p".
- Sialoadhesin band "13".
- Sialoadhesin caption "Structure of the N-terimal domain of mouse sialoadhesin.".
- Sialoadhesin chromosome "20".
- Sialoadhesin entrezgene "6614".
- Sialoadhesin hasPhotoCollection Sialoadhesin.
- Sialoadhesin hgncid "11127".
- Sialoadhesin name "Sialoadhesin".
- Sialoadhesin omim "600751".
- Sialoadhesin pdb "2".
- Sialoadhesin refseq "NM_023068".
- Sialoadhesin symbol "SIGLEC1".
- Sialoadhesin uniprot "Q9BZZ2".
- Sialoadhesin wikiPageUsesTemplate Template:Clusters_of_differentiation.
- Sialoadhesin wikiPageUsesTemplate Template:Lectins.
- Sialoadhesin wikiPageUsesTemplate Template:Membrane-protein-stub.
- Sialoadhesin wikiPageUsesTemplate Template:Protein.
- Sialoadhesin wikiPageUsesTemplate Template:Reflist.
- Sialoadhesin subject Category:Clusters_of_differentiation.
- Sialoadhesin subject Category:SIGLEC.
- Sialoadhesin hypernym Molecule.
- Sialoadhesin type Biomolecule.
- Sialoadhesin type ChemicalCompound.
- Sialoadhesin type Protein.
- Sialoadhesin type Chemical.
- Sialoadhesin type Thing.
- Sialoadhesin type Q206229.
- Sialoadhesin type Q8054.
- Sialoadhesin comment "Sialoadhesin is a cell adhesion molecule found on the surface of certain cells of the immune system called macrophages. It is found in especially high amounts on macrophages of the spleen, liver, lymph node, bone marrow, colon, and lungs. Also, in patients suffering from rheumatoid arthritis, the protein has been found in great amounts on macrophages of the affected tissues.".
- Sialoadhesin label "Sialoadhesin".
- Sialoadhesin sameAs m.02pq1qy.
- Sialoadhesin sameAs Q7506686.
- Sialoadhesin sameAs Q7506686.
- Sialoadhesin wasDerivedFrom Sialoadhesin?oldid=641601015.
- Sialoadhesin depiction 2BVE.pdb.jpg.
- Sialoadhesin isPrimaryTopicOf Sialoadhesin.
- Sialoadhesin name "Sialoadhesin".