Matches in DBpedia 2015-10 for { <http://dbpedia.org/resource/Presenilin> ?p ?o }
- Presenilin abstract "Presenilins are a family of related multi-pass transmembrane proteins which constitute the catalytic subunits of the gamma-secretase intramembrane protease complex. They were first identified in screens for mutations causing early onset forms of familial Alzheimer's Disease by Peter St George-Hyslop at the Centre for Research in Neurodegenerative Diseases at the University of Toronto, and now also at the University of Cambridge. Vertebrates have two presenilin genes, called PSEN1 (located on chromosome 14 in humans) that encodes presenilin 1 (PS-1) and PSEN2 (on chromosome 1 in humans) that codes for presenilin 2 (PS-2). Both genes show conservation between species, with little difference between rat and human presenilins. The nematode worm C. elegans has two genes that resemble the presenilins and appear to be functionally similar, sel-12 and hop-1.Presenilins undergo cleavage in an alpha helical region of one of the cytoplasmic loops to produce a large N-terminal and a smaller C-terminal fragment that together form part of the functional protein. Cleavage of presenilin 1 can be prevented by a mutation that causes the loss of exon 9, and results in loss of function. Presenilins play a key role in the modulation of intracellular Ca2+ involved in presynaptic neurotransmitter release and long-term potentiation induction.Dominant mutations in the genes that encode presenilin proteins are the most common cause of familial early-onset Alzheimer's disease.".
- Presenilin arm "q".
- Presenilin band "24.3".
- Presenilin band "31".
- Presenilin chromosome "1".
- Presenilin chromosome "14".
- Presenilin ecNumber "3.4.23.-".
- Presenilin entrezgene "5663".
- Presenilin entrezgene "5664".
- Presenilin hgncid "9508".
- Presenilin hgncid "9509".
- Presenilin locusSupplementaryData "-q42".
- Presenilin omim "104311".
- Presenilin omim "600759".
- Presenilin refseq "NM_000021".
- Presenilin refseq "NM_000447".
- Presenilin symbol "AD3".
- Presenilin symbol "AD4".
- Presenilin symbol "PSEN1".
- Presenilin symbol "PSEN2".
- Presenilin symbol "Presenilin".
- Presenilin thumbnail 2KR6.pdb.png?width=300.
- Presenilin uniprot "P49768".
- Presenilin uniprot "P49810".
- Presenilin wikiPageExternalLink merops.cgi?id=A22.001.
- Presenilin wikiPageExternalLink merops.cgi?id=A22.002.
- Presenilin wikiPageExternalLink www.dian-info.org.
- Presenilin wikiPageExternalLink www.dianer.org.
- Presenilin wikiPageExternalLink explore.do?structureId=2KR6.
- Presenilin wikiPageID "7732070".
- Presenilin wikiPageLength "11021".
- Presenilin wikiPageOutDegree "42".
- Presenilin wikiPageRevisionID "679599736".
- Presenilin wikiPageWikiLink Alzheimers_Disease.
- Presenilin wikiPageWikiLink Alzheimers_disease.
- Presenilin wikiPageWikiLink Amyloid_beta.
- Presenilin wikiPageWikiLink Amyloid_precursor_protein.
- Presenilin wikiPageWikiLink Autosomal_dominant.
- Presenilin wikiPageWikiLink Beta-secretase_1.
- Presenilin wikiPageWikiLink Beta_secretase.
- Presenilin wikiPageWikiLink C-terminal.
- Presenilin wikiPageWikiLink C-terminus.
- Presenilin wikiPageWikiLink Caenorhabditis_elegans.
- Presenilin wikiPageWikiLink Category:Moonlighting_proteins.
- Presenilin wikiPageWikiLink Cell_membrane.
- Presenilin wikiPageWikiLink Centre_for_Research_in_Neurodegenerative_Diseases.
- Presenilin wikiPageWikiLink Chromosome_1.
- Presenilin wikiPageWikiLink Chromosome_14.
- Presenilin wikiPageWikiLink Chromosome_14_(human).
- Presenilin wikiPageWikiLink Chromosome_1_(human).
- Presenilin wikiPageWikiLink Dominance_(genetics).
- Presenilin wikiPageWikiLink Enzyme.
- Presenilin wikiPageWikiLink Enzymes.
- Presenilin wikiPageWikiLink Gamma-secretase.
- Presenilin wikiPageWikiLink Gamma_secretase.
- Presenilin wikiPageWikiLink Gene.
- Presenilin wikiPageWikiLink Hippocampal.
- Presenilin wikiPageWikiLink Hippocampus.
- Presenilin wikiPageWikiLink Hop-1.
- Presenilin wikiPageWikiLink Intramembrane_protease.
- Presenilin wikiPageWikiLink Long-term_potentiation.
- Presenilin wikiPageWikiLink MEROPS.
- Presenilin wikiPageWikiLink Multiprotein_complex.
- Presenilin wikiPageWikiLink Mutation.
- Presenilin wikiPageWikiLink N-terminal.
- Presenilin wikiPageWikiLink N-terminus.
- Presenilin wikiPageWikiLink Notch_signaling.
- Presenilin wikiPageWikiLink Notch_signaling_pathway.
- Presenilin wikiPageWikiLink PSEN1.
- Presenilin wikiPageWikiLink PSEN2.
- Presenilin wikiPageWikiLink Peter_St_George-Hyslop.
- Presenilin wikiPageWikiLink Plasma_membrane.
- Presenilin wikiPageWikiLink Protein.
- Presenilin wikiPageWikiLink Protein_complex.
- Presenilin wikiPageWikiLink Sel-12.
- Presenilin wikiPageWikiLink Theta_rhythm.
- Presenilin wikiPageWikiLink University_of_Cambridge.
- Presenilin wikiPageWikiLink University_of_Toronto.
- Presenilin wikiPageWikiLink X-ray_crystallography.
- Presenilin wikiPageWikiLinkText "''presenilins 1 and 2''".
- Presenilin wikiPageWikiLinkText "Presenilin".
- Presenilin wikiPageWikiLinkText "presenilin".
- Presenilin wikiPageWikiLinkText "presenilin-1".
- Presenilin wikiPageWikiLinkText "ps1".
- Presenilin wikiPageWikiLinkText "ps2".
- Presenilin altsymbols "AD3".
- Presenilin altsymbols "AD4".
- Presenilin arm "q".
- Presenilin band "24.3".
- Presenilin band "31".
- Presenilin caption "Solution structure of the human presenilin-1 CTF subunit.".
- Presenilin chromosome "1".
- Presenilin chromosome "14".
- Presenilin ecnumber "3.4".
- Presenilin entrezgene "5663".
- Presenilin entrezgene "5664".
- Presenilin hasPhotoCollection Presenilin.
- Presenilin hgncid "9508".
- Presenilin hgncid "9509".
- Presenilin interpro "IPR001108".