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- Potency_(pharmacology) abstract "In the field of pharmacology, potency is a measure of drug activity expressed in terms of the amount required to produce an effect of given intensity. A highly potent drug (e.g., fentanyl, alprazolam, risperidone) evokes a larger response at low concentrations, while a drug of lower potency (codiene, diazepam, ziprasidone) evokes a small response at low concentrations. It is proportional to affinity and efficacy.Affinity is the ability of the drug to bind to a receptor. Efficacy is the relationship between receptor occupancy and the ability to initiate a response at the molecular, cellular, tissue or system level. The response is equal to the effect, or (E), and depends on both the drug binding and the drug-bound receptor then producing a response; thus, potency depends on both affinity and efficacy. The agonist, the ligand, drug or hormone that binds to the receptor and initiates the response is usually abbreviated A or D. Below a certain concentration of agonist ([A]), E is too low to measure but at higher concentrations it becomes appreciable and rises with increasing agonist concentration [A] until at sufficiently high concentrations it can no longer be increased by raising [A] and asymptotes to a maximum Emax. The Emax is the maximum possible effect for the agonist. The concentration of A at which E is 50% of Emax is termed the half maximal effective concentration and is abbreviated [A]50, or more commonly EC50. The term "potency" refers to the [A]50 value. The lower the [A]50, the less the concentration of a drug is required to produce 50% of maximum effect and the higher the potency.Higher potency does not necessarily mean more side effects.".
- Potency_(pharmacology) thumbnail Potency_pharmacology.svg?width=300.
- Potency_(pharmacology) wikiPageExternalLink formulating-high-potency-drugs.
- Potency_(pharmacology) wikiPageID "12732624".
- Potency_(pharmacology) wikiPageLength "3634".
- Potency_(pharmacology) wikiPageOutDegree "16".
- Potency_(pharmacology) wikiPageRevisionID "680760652".
- Potency_(pharmacology) wikiPageWikiLink Adverse_drug_reaction.
- Potency_(pharmacology) wikiPageWikiLink Alprazolam.
- Potency_(pharmacology) wikiPageWikiLink Category:Pharmacodynamics.
- Potency_(pharmacology) wikiPageWikiLink Codeine.
- Potency_(pharmacology) wikiPageWikiLink Codiene.
- Potency_(pharmacology) wikiPageWikiLink Diazepam.
- Potency_(pharmacology) wikiPageWikiLink Dissociation_constant.
- Potency_(pharmacology) wikiPageWikiLink EC50.
- Potency_(pharmacology) wikiPageWikiLink Fentanyl.
- Potency_(pharmacology) wikiPageWikiLink Half_maximal_effective_concentration.
- Potency_(pharmacology) wikiPageWikiLink Intrinsic_activity.
- Potency_(pharmacology) wikiPageWikiLink Occupational_exposure_limit.
- Potency_(pharmacology) wikiPageWikiLink Occupational_exposure_limits.
- Potency_(pharmacology) wikiPageWikiLink Pharmacology.
- Potency_(pharmacology) wikiPageWikiLink Risperidone.
- Potency_(pharmacology) wikiPageWikiLink Ziprasidone.
- Potency_(pharmacology) wikiPageWikiLink File:Potency_pharmacology.svg.
- Potency_(pharmacology) wikiPageWikiLinkText "Bmax".
- Potency_(pharmacology) wikiPageWikiLinkText "Drug potency".
- Potency_(pharmacology) wikiPageWikiLinkText "Potency (pharmacology)".
- Potency_(pharmacology) wikiPageWikiLinkText "Potency".
- Potency_(pharmacology) wikiPageWikiLinkText "affinity".
- Potency_(pharmacology) wikiPageWikiLinkText "biologically potent".
- Potency_(pharmacology) wikiPageWikiLinkText "effective".
- Potency_(pharmacology) wikiPageWikiLinkText "lethal".
- Potency_(pharmacology) wikiPageWikiLinkText "potencies".
- Potency_(pharmacology) wikiPageWikiLinkText "potency".
- Potency_(pharmacology) wikiPageWikiLinkText "potent".
- Potency_(pharmacology) wikiPageWikiLinkText "potently".
- Potency_(pharmacology) wikiPageWikiLinkText "stronger".
- Potency_(pharmacology) wikiPageWikiLinkText "subpotency, or superpotency".
- Potency_(pharmacology) wikiPageWikiLinkText "the potency".
- Potency_(pharmacology) hasPhotoCollection Potency_(pharmacology).
- Potency_(pharmacology) wikiPageUsesTemplate Template:Cite_book.
- Potency_(pharmacology) wikiPageUsesTemplate Template:Cite_news.
- Potency_(pharmacology) wikiPageUsesTemplate Template:Pharmacology.
- Potency_(pharmacology) wikiPageUsesTemplate Template:Pharmacology-stub.
- Potency_(pharmacology) wikiPageUsesTemplate Template:Reflist.
- Potency_(pharmacology) subject Category:Pharmacodynamics.
- Potency_(pharmacology) hypernym Measure.
- Potency_(pharmacology) type Work.
- Potency_(pharmacology) comment "In the field of pharmacology, potency is a measure of drug activity expressed in terms of the amount required to produce an effect of given intensity. A highly potent drug (e.g., fentanyl, alprazolam, risperidone) evokes a larger response at low concentrations, while a drug of lower potency (codiene, diazepam, ziprasidone) evokes a small response at low concentrations. It is proportional to affinity and efficacy.Affinity is the ability of the drug to bind to a receptor.".
- Potency_(pharmacology) label "Potency (pharmacology)".
- Potency_(pharmacology) sameAs فاعلية_دوائية.
- Potency_(pharmacology) sameAs قدرت_اثر.
- Potency_(pharmacology) sameAs פוטנטיות.
- Potency_(pharmacology) sameAs Potenza_(farmacologia).
- Potency_(pharmacology) sameAs m.02x2jrt.
- Potency_(pharmacology) sameAs Молярная_активность_лиганда.
- Potency_(pharmacology) sameAs Potentnost_(farmakologija).
- Potency_(pharmacology) sameAs Potentnost_(farmakologija).
- Potency_(pharmacology) sameAs Q2066956.
- Potency_(pharmacology) sameAs Q2066956.
- Potency_(pharmacology) sameAs 潜能_(药理学).
- Potency_(pharmacology) wasDerivedFrom Potency_(pharmacology)?oldid=680760652.
- Potency_(pharmacology) depiction Potency_pharmacology.svg.
- Potency_(pharmacology) isPrimaryTopicOf Potency_(pharmacology).