Matches in DBpedia 2015-10 for { <http://dbpedia.org/resource/P14arf> ?p ?o }
- P14arf abstract "p14ARF (also called ARF tumor suppressor, ARF, p14ARF) is an alternate reading frame protein product of the CDKN2A locus (i.e. INK4a/ARF locus). p14ARF is induced in response to elevated mitogenic stimulation, such as aberrant growth signaling from MYC and Ras (protein). It accumulates mainly in the nucleolus where it forms stable complexes with NPM or Mdm2. These interactions allow p14ARF to act as a tumor suppressor by inhibiting ribosome biogenesis or initiating p53-dependent cell cycle arrest and apoptosis, respectively. p14ARF is an atypical protein, in terms of its transcription, its amino acid composition, and its degradation: it is transcribed in an alternate reading frame of a different protein, it is highly basic, and it is polyubiquinated at the N-terminus.Both p16INK4a and p14ARF are involved in cell cycle regulation. p14ARF inhibits mdm2, thus promoting p53, which promotes p21 activation, which then binds and inactivates certain cyclin-CDK complexes, which would otherwise promote transcription of genes that would carry the cell through the G1/S checkpoint of the cell cycle. Loss of p14ARF by a homozygous mutation in the CDKN2A (INK4A) gene will lead to elevated levels in mdm2 and, therefore, loss of p53 function and cell cycle control.The equivalent in mice is p19ARF.".
- P14arf arm "p".
- P14arf band "21".
- P14arf chromosome "9".
- P14arf entrezgene "1029".
- P14arf hgncid "1787".
- P14arf omim "600160".
- P14arf refseq "NM_058195".
- P14arf symbol "CDKN2, MLM".
- P14arf symbol "CDKN2A".
- P14arf uniprot "P42771".
- P14arf wikiPageExternalLink pmidlookup?view=long&pmid=10646864.
- P14arf wikiPageExternalLink S1097-2765(00)80351-2.
- P14arf wikiPageID "6766548".
- P14arf wikiPageLength "23396".
- P14arf wikiPageOutDegree "118".
- P14arf wikiPageRevisionID "673308076".
- P14arf wikiPageWikiLink Acetylated.
- P14arf wikiPageWikiLink Acetylation.
- P14arf wikiPageWikiLink Adenoma.
- P14arf wikiPageWikiLink Adenomas.
- P14arf wikiPageWikiLink Amino_acid.
- P14arf wikiPageWikiLink Apoptosis.
- P14arf wikiPageWikiLink Apoptotic.
- P14arf wikiPageWikiLink Autophagy.
- P14arf wikiPageWikiLink CDK4.
- P14arf wikiPageWikiLink CDK6.
- P14arf wikiPageWikiLink Cancer.
- P14arf wikiPageWikiLink Carcinogenesis.
- P14arf wikiPageWikiLink Category:Human_genes.
- P14arf wikiPageWikiLink Cell_(biology).
- P14arf wikiPageWikiLink Cell_cycle.
- P14arf wikiPageWikiLink Cell_cycle_checkpoint.
- P14arf wikiPageWikiLink Cell_growth.
- P14arf wikiPageWikiLink Cell_nucleus.
- P14arf wikiPageWikiLink Cell_proliferation.
- P14arf wikiPageWikiLink Chaperone_(protein).
- P14arf wikiPageWikiLink Chromosome.
- P14arf wikiPageWikiLink Cyclin.
- P14arf wikiPageWikiLink Cyclin-dependent_kinase.
- P14arf wikiPageWikiLink Cyclin-dependent_kinase_4.
- P14arf wikiPageWikiLink Cyclin-dependent_kinase_6.
- P14arf wikiPageWikiLink Cytoplasm.
- P14arf wikiPageWikiLink DNA.
- P14arf wikiPageWikiLink E2F.
- P14arf wikiPageWikiLink Enzyme.
- P14arf wikiPageWikiLink Eukaryote.
- P14arf wikiPageWikiLink Eukaryotic.
- P14arf wikiPageWikiLink Exon.
- P14arf wikiPageWikiLink Exons.
- P14arf wikiPageWikiLink G1_phase.
- P14arf wikiPageWikiLink Gene.
- P14arf wikiPageWikiLink Genes.
- P14arf wikiPageWikiLink Glioblastoma.
- P14arf wikiPageWikiLink Glioblastoma_multiforme.
- P14arf wikiPageWikiLink Half-life.
- P14arf wikiPageWikiLink Hydrophobe.
- P14arf wikiPageWikiLink Hydrophobic.
- P14arf wikiPageWikiLink Interphase.
- P14arf wikiPageWikiLink Isoform.
- P14arf wikiPageWikiLink Isoforms.
- P14arf wikiPageWikiLink Lysine.
- P14arf wikiPageWikiLink MYC.
- P14arf wikiPageWikiLink Mdm2.
- P14arf wikiPageWikiLink Methionine.
- P14arf wikiPageWikiLink Methylation.
- P14arf wikiPageWikiLink Mitochondria.
- P14arf wikiPageWikiLink Mitochondrial.
- P14arf wikiPageWikiLink Mitochondrial_matrix.
- P14arf wikiPageWikiLink Mitochondrion.
- P14arf wikiPageWikiLink Mitogen.
- P14arf wikiPageWikiLink Mitogenic.
- P14arf wikiPageWikiLink Mutation.
- P14arf wikiPageWikiLink Myc.
- P14arf wikiPageWikiLink N-terminus.
- P14arf wikiPageWikiLink NPM1.
- P14arf wikiPageWikiLink Nuclear_localization_sequence.
- P14arf wikiPageWikiLink Nuclear_localization_signal.
- P14arf wikiPageWikiLink Nucleolus.
- P14arf wikiPageWikiLink Nucleophosmin.
- P14arf wikiPageWikiLink Oncogene.
- P14arf wikiPageWikiLink Oncogenic.
- P14arf wikiPageWikiLink P16.
- P14arf wikiPageWikiLink P16INK4a.
- P14arf wikiPageWikiLink P16_(gene).
- P14arf wikiPageWikiLink P21.
- P14arf wikiPageWikiLink P53.
- P14arf wikiPageWikiLink Phosphorylate.
- P14arf wikiPageWikiLink Phosphorylated.
- P14arf wikiPageWikiLink Phosphorylation.
- P14arf wikiPageWikiLink Promoter_(biology).
- P14arf wikiPageWikiLink Promoter_(genetics).
- P14arf wikiPageWikiLink Protease.
- P14arf wikiPageWikiLink Proteases.
- P14arf wikiPageWikiLink Proteasome.
- P14arf wikiPageWikiLink Protein.
- P14arf wikiPageWikiLink Protein_isoform.
- P14arf wikiPageWikiLink RRNA.
- P14arf wikiPageWikiLink Ras_(protein).
- P14arf wikiPageWikiLink Ras_subfamily.