Matches in DBpedia 2015-10 for { <http://dbpedia.org/resource/Dynorphin> ?p ?o }
- Dynorphin abstract "Dynorphins (Dyn) are a class of opioid peptides that arise from the precursor protein prodynorphin. When prodynorphin is cleaved during processing by proprotein convertase 2 (PC2), multiple active peptides are released: dynorphin A, dynorphin B, and α/β-neo-endorphin. Depolarization of a neuron containing prodynorphin stimulates PC2 processing, which occurs within synaptic vesicles in the presynaptic terminal. Occasionally, prodynorphin is not fully processed, leading to the release of “big dynorphin.” This 32-amino acid molecule consists of both dynorphin A and dynorphin B.Dynorphin A, dynorphin B, and big dynorphin all contain a high proportion of basic amino acid residues, in particular lysine and arginine (29.4%, 23.1%, and 31.2% basic residues, respectively), as well as many hydrophobic residues (41.2%, 30.8%, and 34.4% hydrophobic residues, respectively). Although dynorphins are found widely distributed in the CNS, they have the highest concentrations in the hypothalamus, medulla, pons, midbrain, and spinal cord. Dynorphins are stored in large (80-120 nm diameter) dense-core vesicles that are considerably larger than vesicles storing neurotransmitters. These large dense-core vesicles differ from small synaptic vesicles in that a more intense and prolonged stimulus is needed to cause the large vesicles to release their contents into the synaptic cleft. Dense-core vesicle storage is characteristic of opioid peptides storage.The first clues to the functionality of dynorphins came from Goldstein et al. in their work with opioid peptides. The group discovered an endogenous opioid peptide in the porcine pituitary that proved difficult to isolate. By sequencing the first 13 amino acids of the peptide, they created a synthetic version of the peptide with a similar potency to the natural peptide. Goldstein et al. applied the synthetic peptide to the guinea ileum longitudinal muscle and found it to be an extraordinarily potent opioid peptide. The peptide was called dynorphin (from the Greek dynamis=power) to describe its potency.Dynorphins exert their effects primarily through the κ-opioid receptor (KOR), a G-protein-coupled receptor. Two subtypes of KORs have been identified: K1 and K2. Although KOR is the primary receptor for all dynorphins, the peptides do have some affinity for the μ-opioid receptor (MOR), δ-opioid receptor (DOR),and the N-methyl-D-aspartic acid (NMDA)-type glutamate receptor. Different dynorphins show different receptor selectivities and potencies at receptors. Big dynorphin and dynorphin A have the same selectivity for human KOR, but dynorphin A is more selective for KOR over MOR and DOR than is big dynorphin. Big dynorphin is more potent at KORs than is dynorphin A. Both big dynorphin and dynorphin A are more potent and more selective than dynorphin B.".
- Dynorphin arm "p".
- Dynorphin band "ter".
- Dynorphin chromosome "20".
- Dynorphin entrezgene "5173".
- Dynorphin hgncid "8820".
- Dynorphin locusSupplementaryData "-p12.2".
- Dynorphin omim "131340".
- Dynorphin refseq "NM_024411".
- Dynorphin symbol "PDYN".
- Dynorphin uniprot "P01213".
- Dynorphin wikiPageExternalLink index.html?query=pdyn.
- Dynorphin wikiPageID "710793".
- Dynorphin wikiPageLength "34585".
- Dynorphin wikiPageOutDegree "70".
- Dynorphin wikiPageRevisionID "667718842".
- Dynorphin wikiPageWikiLink Allen_Brain_Atlas.
- Dynorphin wikiPageWikiLink Alpha-Neoendorphin.
- Dynorphin wikiPageWikiLink Appetite.
- Dynorphin wikiPageWikiLink Arcuate_nucleus.
- Dynorphin wikiPageWikiLink Astrocyte.
- Dynorphin wikiPageWikiLink Beta-Neoendorphin.
- Dynorphin wikiPageWikiLink Big_dynorphin.
- Dynorphin wikiPageWikiLink CREB.
- Dynorphin wikiPageWikiLink Category:Depressogenics.
- Dynorphin wikiPageWikiLink Category:Kappa_agonists.
- Dynorphin wikiPageWikiLink Category:Neurotransmitters.
- Dynorphin wikiPageWikiLink Category:Opioid_peptides.
- Dynorphin wikiPageWikiLink Chemical_synapse.
- Dynorphin wikiPageWikiLink Circadian_rhythm.
- Dynorphin wikiPageWikiLink Circadian_rhythms.
- Dynorphin wikiPageWikiLink Corticotropin-releasing_factor.
- Dynorphin wikiPageWikiLink Corticotropin-releasing_factor_family.
- Dynorphin wikiPageWikiLink Cyclic_adenosine_monophosphate.
- Dynorphin wikiPageWikiLink Dense-core_vesicles.
- Dynorphin wikiPageWikiLink Depression_(mood).
- Dynorphin wikiPageWikiLink Dopamine.
- Dynorphin wikiPageWikiLink Dynorphin_A.
- Dynorphin wikiPageWikiLink Dynorphin_B.
- Dynorphin wikiPageWikiLink Dysphoria.
- Dynorphin wikiPageWikiLink G-protein-coupled_receptor.
- Dynorphin wikiPageWikiLink G_protein–coupled_receptor.
- Dynorphin wikiPageWikiLink Glutamate.
- Dynorphin wikiPageWikiLink Glutamic_acid.
- Dynorphin wikiPageWikiLink Hippocampus.
- Dynorphin wikiPageWikiLink Homeostasis.
- Dynorphin wikiPageWikiLink Hyperthermia.
- Dynorphin wikiPageWikiLink Hypothalamus.
- Dynorphin wikiPageWikiLink Hypothermia.
- Dynorphin wikiPageWikiLink Knockout_mice.
- Dynorphin wikiPageWikiLink Knockout_mouse.
- Dynorphin wikiPageWikiLink Lateral_hypothalamus.
- Dynorphin wikiPageWikiLink Learned_helplessness.
- Dynorphin wikiPageWikiLink Medulla_oblongata.
- Dynorphin wikiPageWikiLink Microdialysis.
- Dynorphin wikiPageWikiLink Microglia.
- Dynorphin wikiPageWikiLink Midbrain.
- Dynorphin wikiPageWikiLink Morphine.
- Dynorphin wikiPageWikiLink N-Methyl-D-aspartic_acid.
- Dynorphin wikiPageWikiLink NMDA.
- Dynorphin wikiPageWikiLink Naloxone.
- Dynorphin wikiPageWikiLink Negative_feedback.
- Dynorphin wikiPageWikiLink Neuron.
- Dynorphin wikiPageWikiLink Neuroplasticity.
- Dynorphin wikiPageWikiLink Neurotransmitter.
- Dynorphin wikiPageWikiLink Neurotransmitters.
- Dynorphin wikiPageWikiLink Nitric_oxide.
- Dynorphin wikiPageWikiLink Northern_blot.
- Dynorphin wikiPageWikiLink Nucleus_accumbens.
- Dynorphin wikiPageWikiLink Opioid_peptide.
- Dynorphin wikiPageWikiLink Opioid_peptides.
- Dynorphin wikiPageWikiLink Orexin.
- Dynorphin wikiPageWikiLink Oxytocin.
- Dynorphin wikiPageWikiLink Pons.
- Dynorphin wikiPageWikiLink Posterior_grey_column.
- Dynorphin wikiPageWikiLink Posterior_horn_of_spinal_cord.
- Dynorphin wikiPageWikiLink Prodynorphin.
- Dynorphin wikiPageWikiLink Proprotein_convertase_2.
- Dynorphin wikiPageWikiLink Prostaglandin.
- Dynorphin wikiPageWikiLink Protein.
- Dynorphin wikiPageWikiLink Protein_kinase_A.
- Dynorphin wikiPageWikiLink Spinal_cord.
- Dynorphin wikiPageWikiLink Striatum.
- Dynorphin wikiPageWikiLink Substantia_nigra.
- Dynorphin wikiPageWikiLink Supraoptic_nucleus.
- Dynorphin wikiPageWikiLink Synaptic_cleft.
- Dynorphin wikiPageWikiLink Vasopressin.
- Dynorphin wikiPageWikiLink Vesicle_(biology).
- Dynorphin wikiPageWikiLink Vesicle_(biology_and_chemistry).
- Dynorphin wikiPageWikiLink Α-neo-endorphin.
- Dynorphin wikiPageWikiLink Β-neo-endorphin.
- Dynorphin wikiPageWikiLink Δ-opioid_receptor.
- Dynorphin wikiPageWikiLink Κ-opioid_receptor.
- Dynorphin wikiPageWikiLink Μ-opioid_receptor.
- Dynorphin wikiPageWikiLinkText "Dynorphin".
- Dynorphin wikiPageWikiLinkText "dynorphin".
- Dynorphin arm "p".
- Dynorphin band "ter".
- Dynorphin chromosome "20".
- Dynorphin entrezgene "5173".