Matches in DBpedia 2015-10 for { ?s ?p "Transthyretin Amyloid Cardiomyopathy (ATTR-CM), or Familial Amyloid Cardiomyopathy (FAC), results from the aggregation of mutant and/or wild-type transthyretin protein in the heart. Both mutant and wild-type transthyretin comprise the aggregates because the TTR blood protein is a tetramer composed of mutant and wild-type TTR subunits in heterozygotes. The TTR tetramer has to dissociate in a rate-limiting step before the monomer can misfold and become aggregation competent."@en }
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- Familial_amyloid_cardiomyopathy comment "Transthyretin Amyloid Cardiomyopathy (ATTR-CM), or Familial Amyloid Cardiomyopathy (FAC), results from the aggregation of mutant and/or wild-type transthyretin protein in the heart. Both mutant and wild-type transthyretin comprise the aggregates because the TTR blood protein is a tetramer composed of mutant and wild-type TTR subunits in heterozygotes. The TTR tetramer has to dissociate in a rate-limiting step before the monomer can misfold and become aggregation competent.".