Matches in DBpedia 2015-10 for { ?s ?p "The catalytically competent protonation state (CCPS) is the catalytically active protonation state of an enzyme.An enzyme is a protein, which catalyzes a chemical reaction. Proteins and enzymes consist of amino acids, some of which are titratable (i.e. they can alter their charge when the pH of the solution changes), and an enzyme commonly needs a set of specific residues in its active site to occupy a specific protonation state to be catalytically active.An example of this phenomenon is provided by Hen Egg White Lysozyme (HEWL) - a Lysozyme, which has two acidic residues in its active site that are important for catalytic activity: Glu35 and Asp 52. For HEWL to be catalytically active, Glu35 must be neutral (i.e. be protonated), whereas Asp 52 must be negatively charged (i.e. it has lost its proton).The protonation state Glu35H,Asp52- is thus the catatlytically competent protonation state of HEWL, where H denotes the protonated form of the Glu."@en }
Showing triples 1 to 1 of
1
with 100 triples per page.
- Catalytically_competent_protonation_state abstract "The catalytically competent protonation state (CCPS) is the catalytically active protonation state of an enzyme.An enzyme is a protein, which catalyzes a chemical reaction. Proteins and enzymes consist of amino acids, some of which are titratable (i.e. they can alter their charge when the pH of the solution changes), and an enzyme commonly needs a set of specific residues in its active site to occupy a specific protonation state to be catalytically active.An example of this phenomenon is provided by Hen Egg White Lysozyme (HEWL) - a Lysozyme, which has two acidic residues in its active site that are important for catalytic activity: Glu35 and Asp 52. For HEWL to be catalytically active, Glu35 must be neutral (i.e. be protonated), whereas Asp 52 must be negatively charged (i.e. it has lost its proton).The protonation state Glu35H,Asp52- is thus the catatlytically competent protonation state of HEWL, where H denotes the protonated form of the Glu.".