Matches in DBpedia 2015-10 for { ?s ?p "The Cope reaction or Cope elimination, developed by Arthur C. Cope, is an elimination reaction of the N-oxide of a tertiary amine to form an alkene and a hydroxylamine. The reaction mechanism involves an intramolecular 5-membered cyclic transition state, leading to a syn elimination product, an Ei pathway. This organic reaction gives the same result as the Hofmann elimination, but the base is a part of the leaving group. The amine oxide is prepared by oxidation of the corresponding amine with an oxidant such as mCPBA. The actual elimination just requires heat.An application is a synthesis of methylenecyclohexane:synthesis of methylenecyclohexanePiperidines are resistant to an intramolecular Cope reaction but with pyrrolidine and with rings of size 7 and larger, the reaction product is an unsaturated hydroxyl amine. This result is consistent with the 5-membered cyclic transition state. intramolecular Cope reaction↑ ↑ ↑ ↑"@en }
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- Cope_reaction abstract "The Cope reaction or Cope elimination, developed by Arthur C. Cope, is an elimination reaction of the N-oxide of a tertiary amine to form an alkene and a hydroxylamine. The reaction mechanism involves an intramolecular 5-membered cyclic transition state, leading to a syn elimination product, an Ei pathway. This organic reaction gives the same result as the Hofmann elimination, but the base is a part of the leaving group. The amine oxide is prepared by oxidation of the corresponding amine with an oxidant such as mCPBA. The actual elimination just requires heat.An application is a synthesis of methylenecyclohexane:synthesis of methylenecyclohexanePiperidines are resistant to an intramolecular Cope reaction but with pyrrolidine and with rings of size 7 and larger, the reaction product is an unsaturated hydroxyl amine. This result is consistent with the 5-membered cyclic transition state. intramolecular Cope reaction↑ ↑ ↑ ↑".