DBpedia – Linked Data Fragments

Matches in DBpedia 2015-10 for { ?s ?p "In molecular biology, the anaerobic C4-dicarboxylate membrane transporter protein family (or C4-dicarboxylate Uptake (Dcu) family) is a family of proteins which includes the DcuA, DcuB and DcuC proteins. Many members of this family are predicted to have 12 GES predicted transmembrane regions, however the one member of this family whose membrane topology has been experimentally determined has 10 transmembrane regions, with both the N- and C-termini localized to the periplasm.The DcuA and DcuB proteins are involved in the transport of aspartate, malate, fumarate and succinate in many species and are thought to function as antiporters with any two of these substrates. Since DcuA is encoded in an operon with the gene for aspartase, and DcuB is encoded in an operon with the gene for fumarase, their physiological functions may be to catalyse aspartate:fumarate and fumarate:malate exchange during the anaerobic utilization of aspartate and fumarate, respectively. The Escherichia coli DcuA and DcuB proteins have very different expression patterns. DcuA is constitutively expressed; DcuB is strongly induced anaerobically by FNR and C4-dicarboxylates, while it is repressed by nitrate and subject to CRP-mediated catabolite repression. DcuB is the major C4-dicarboxylate carrier for fumarate respiration with high fumarate-succinate exchange activity. It is synthesized only in the absence of oxygen and nitrate and in the presence of C4-dicarboxylates. DcuA is expressed constitutively in aerobic and anaerobic growth and can substitute for DcuB.DcuC has 12 GES predicted transmembrane regions, is induced only under anaerobic conditions, and is not repressed by glucose. DcuC may therefore function as a succinate efflux system during anaerobic glucose fermentation. However, when overexpressed, it can replace either DcuA or DcuB in catalysing fumarate-succinate exchange and fumarate uptake. DcuC shows the same transport modes as DcuA and DcuB (exchange, uptake, and presumably efflux of C4-dicarboxylates)."@en }

• Anaerobic_C4-dicarboxylate_membrane_transporter_protein abstract "In molecular biology, the anaerobic C4-dicarboxylate membrane transporter protein family (or C4-dicarboxylate Uptake (Dcu) family) is a family of proteins which includes the DcuA, DcuB and DcuC proteins. Many members of this family are predicted to have 12 GES predicted transmembrane regions, however the one member of this family whose membrane topology has been experimentally determined has 10 transmembrane regions, with both the N- and C-termini localized to the periplasm.The DcuA and DcuB proteins are involved in the transport of aspartate, malate, fumarate and succinate in many species and are thought to function as antiporters with any two of these substrates. Since DcuA is encoded in an operon with the gene for aspartase, and DcuB is encoded in an operon with the gene for fumarase, their physiological functions may be to catalyse aspartate:fumarate and fumarate:malate exchange during the anaerobic utilization of aspartate and fumarate, respectively. The Escherichia coli DcuA and DcuB proteins have very different expression patterns. DcuA is constitutively expressed; DcuB is strongly induced anaerobically by FNR and C4-dicarboxylates, while it is repressed by nitrate and subject to CRP-mediated catabolite repression. DcuB is the major C4-dicarboxylate carrier for fumarate respiration with high fumarate-succinate exchange activity. It is synthesized only in the absence of oxygen and nitrate and in the presence of C4-dicarboxylates. DcuA is expressed constitutively in aerobic and anaerobic growth and can substitute for DcuB.DcuC has 12 GES predicted transmembrane regions, is induced only under anaerobic conditions, and is not repressed by glucose. DcuC may therefore function as a succinate efflux system during anaerobic glucose fermentation. However, when overexpressed, it can replace either DcuA or DcuB in catalysing fumarate-succinate exchange and fumarate uptake. DcuC shows the same transport modes as DcuA and DcuB (exchange, uptake, and presumably efflux of C4-dicarboxylates).".