Matches in DBpedia 2015-10 for { ?s ?p "Grapefruit and grapefruit juice have been found to interact with numerous drugs (at least 85 known by 2013), in many cases resulting in adverse effects. Organic compounds that are furanocoumarin derivatives interfere with the hepatic and intestinal enzyme cytochrome P450 isoform CYP3A4 and are believed to be primarily responsible for the effects of grapefruit on the enzyme. Bioactive compounds in grapefruit juice may also interfere with P-glycoprotein and organic anion transporting polypeptides (OATPs), either increasing or decreasing the bioavailability of a number of drugs. Pomelo (the Asian fruit which was crossed with an orange to produce grapefruit) also contains high amounts of furanocoumarin derivatives. Grapefruit relatives and other pomelo descendants have variable amounts of furanocoumarins."@en }
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- Grapefruit–drug_interactions abstract "Grapefruit and grapefruit juice have been found to interact with numerous drugs (at least 85 known by 2013), in many cases resulting in adverse effects. Organic compounds that are furanocoumarin derivatives interfere with the hepatic and intestinal enzyme cytochrome P450 isoform CYP3A4 and are believed to be primarily responsible for the effects of grapefruit on the enzyme. Bioactive compounds in grapefruit juice may also interfere with P-glycoprotein and organic anion transporting polypeptides (OATPs), either increasing or decreasing the bioavailability of a number of drugs. Pomelo (the Asian fruit which was crossed with an orange to produce grapefruit) also contains high amounts of furanocoumarin derivatives. Grapefruit relatives and other pomelo descendants have variable amounts of furanocoumarins.".