Matches in DBpedia 2015-10 for { ?s ?p "David P. Bartel Ph.D. is a Professor of Biology at the Massachusetts Institute of Technology, Member of the Whitehead Institute, and investigator of the Howard Hughes Medical Institute (HHMI). He earned his B.A. in Biology from Goshen College and his Ph.D. in Virology from Harvard University under the mentorship of Jack W. Szostak.While in the Szostak lab, Bartel isolated the first ribozymes directly from random sequence, using in vitro evolution (among these, the Class I ligase). After he became independent at the Whitehead Institute, he further evolved this ribozyme to function as a RNA-dependent RNA polymerase to extend primers on external RNA templates, bolstering the "RNA world" theory.Bartel later shifted his research focus towards microRNA biology and in particular on understanding their regulatory functions. His lab was one of three that found that animals have many of these small regulatory RNAs, and he was the first to describe microRNAs in plants. Through his work with microRNAs, he developed a methodology that predicts their regulatory targets and created the web-based tool TargetScan, which calculates a microRNA’s targets based on its seed region. His research has also shown that most human mRNAs are regulated by microRNAs.In 2006, he was placed second by Thomson Reuters in a 'citations' ranking in the field of Molecular Biology/Genetics.He has received several awards and was elected to the National Academy of Sciences in 2011."@en }
Showing triples 1 to 1 of
1
with 100 triples per page.
- David_Bartel abstract "David P. Bartel Ph.D. is a Professor of Biology at the Massachusetts Institute of Technology, Member of the Whitehead Institute, and investigator of the Howard Hughes Medical Institute (HHMI). He earned his B.A. in Biology from Goshen College and his Ph.D. in Virology from Harvard University under the mentorship of Jack W. Szostak.While in the Szostak lab, Bartel isolated the first ribozymes directly from random sequence, using in vitro evolution (among these, the Class I ligase). After he became independent at the Whitehead Institute, he further evolved this ribozyme to function as a RNA-dependent RNA polymerase to extend primers on external RNA templates, bolstering the "RNA world" theory.Bartel later shifted his research focus towards microRNA biology and in particular on understanding their regulatory functions. His lab was one of three that found that animals have many of these small regulatory RNAs, and he was the first to describe microRNAs in plants. Through his work with microRNAs, he developed a methodology that predicts their regulatory targets and created the web-based tool TargetScan, which calculates a microRNA’s targets based on its seed region. His research has also shown that most human mRNAs are regulated by microRNAs.In 2006, he was placed second by Thomson Reuters in a 'citations' ranking in the field of Molecular Biology/Genetics.He has received several awards and was elected to the National Academy of Sciences in 2011.".