Matches in DBpedia 2015-10 for { ?s ?p "Chaperone-assisted selective autophagy (CASA) is a cellular process for the selective, ubiquitin-dependent degradation of chaperone-bound proteins in lysosomes.Autophagy (Greek: ‘self-eating’) was initially identified as a catabolic process for the unselective degradation of cellular content in lysosomes under starvation conditions. However, autophagy also comprises selective degradation pathways, which depend on ubiquitin conjugation to initiate sorting to lysosomes. In the case of CASA, dysfunctional, nonnative proteins are recognized by molecular chaperones and become ubiquitinated by chaperone-associated ubiquitin ligases. The ubiquitinated proteins are enclosed in autophagosomes, which eventually fuse with lysosomes, leading to the degradation of the dysfunctional proteins. CASA is a vital part of the cellular protein quality control system. It is essential for protein homeostais (proteostasis) in neurons and in mechanically strained cells and tissues such as skeletal muscle, heart and lung."@en }
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- Chaperone-assisted_selective_autophagy abstract "Chaperone-assisted selective autophagy (CASA) is a cellular process for the selective, ubiquitin-dependent degradation of chaperone-bound proteins in lysosomes.Autophagy (Greek: ‘self-eating’) was initially identified as a catabolic process for the unselective degradation of cellular content in lysosomes under starvation conditions. However, autophagy also comprises selective degradation pathways, which depend on ubiquitin conjugation to initiate sorting to lysosomes. In the case of CASA, dysfunctional, nonnative proteins are recognized by molecular chaperones and become ubiquitinated by chaperone-associated ubiquitin ligases. The ubiquitinated proteins are enclosed in autophagosomes, which eventually fuse with lysosomes, leading to the degradation of the dysfunctional proteins. CASA is a vital part of the cellular protein quality control system. It is essential for protein homeostais (proteostasis) in neurons and in mechanically strained cells and tissues such as skeletal muscle, heart and lung.".