Matches in DBpedia 2015-10 for { ?s ?p "Brevetoxin (PbTx), or brevetoxins, are a suite of cyclic polyether compounds produced naturally by a species of dinoflagellate known as Karenia brevis. Brevetoxins are neurotoxins that bind to voltage-gated sodium channels in nerve cells, leading to disruption of normal neurological processes and causing the illness clinically described as neurotoxic shellfish poisoning (NSP).Although brevetoxins are most well-studied in K. brevis, they are also found in other species of Karenia and at least one large fish kill has been traced to brevetoxins in Chattonella.Other Brevetoxins:Brevetoxin-5 (PbTx-5): like PbTx-3, but acetylated hydroxyl group in position 38.Brevetoxin-6 (PbTx-6): like PbTx-2, but double bond 27-28 is epoxidated.Brevetoxin-B was synthesized in 1995 by K. C. Nicolaou and coworkers in 123 steps with 91% average yield (final yield ~9·10−6). and in 2004 a total of 90 steps with an average 93% yield for each step (0.14% overall).K. C. Nicolaou and coworkers reported their synthesis of Brevetoxin-1 in 1998. In 2009, Michael Crimmins and co-workers reported their synthesis of Brevetoxin-1 as well."@en }
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- Brevetoxin abstract "Brevetoxin (PbTx), or brevetoxins, are a suite of cyclic polyether compounds produced naturally by a species of dinoflagellate known as Karenia brevis. Brevetoxins are neurotoxins that bind to voltage-gated sodium channels in nerve cells, leading to disruption of normal neurological processes and causing the illness clinically described as neurotoxic shellfish poisoning (NSP).Although brevetoxins are most well-studied in K. brevis, they are also found in other species of Karenia and at least one large fish kill has been traced to brevetoxins in Chattonella.Other Brevetoxins:Brevetoxin-5 (PbTx-5): like PbTx-3, but acetylated hydroxyl group in position 38.Brevetoxin-6 (PbTx-6): like PbTx-2, but double bond 27-28 is epoxidated.Brevetoxin-B was synthesized in 1995 by K. C. Nicolaou and coworkers in 123 steps with 91% average yield (final yield ~9·10−6). and in 2004 a total of 90 steps with an average 93% yield for each step (0.14% overall).K. C. Nicolaou and coworkers reported their synthesis of Brevetoxin-1 in 1998. In 2009, Michael Crimmins and co-workers reported their synthesis of Brevetoxin-1 as well.".